The Marshalltown Fire Department was called to a reported structure fire late Thursday morning at 107 West Lincoln Street.
When fire crews arrived on the scene, they found a two-story residence fully engulfed in flames.
Due to the extent of the fire, a defensive operation was established.
Firefighters brought the fire under control and conducted a search of the building with no one found inside.
Local fire crews remained on the scene for two-and-a-half hours.
No injuries were reported.
An investigation is underway and an update will be provided after the investigation is completed.