Kaleb Wesson had 21 points and 12 rebounds to lead the 11th-seeded Buckeyes to a 62-59 upset of sixth-seeded Iowa State in the Midwest Region on Friday night.
Ohio State (20-14), will play No. 3 seed Houston on Sunday for a spot in the round of 16.
Iowa State (23-12) led just once in the second half but had a chance to send the game into overtime when Nick Weiler-Babb had an open attempt at a game-tying 3. His shot missed and ended the season for the Cyclones, who won the Big 12 Tournament to earn a spot in the NCAAs.
“We just weren’t good enough tonight,” Iowa State coach Steve Prohm said. “We still had opportunities down the stretch. We couldn’t get it done. I hate it for these guys because the finale came a lot quicker than I was thinking. I really thought we had a chance to do something.”
Marial Shayok scored 23 points and Lindell Wigginton added 14 for Iowa State.